Osteoporosis is the result of weak bones. Bones are of two types; compact bone and spongy bone. As you know that the minerals are present in the compact bone. The compact bone is hard, which has all the minerals like calcium, potassium in it.
A sufficient amount of calcium is necessary for the integrity of the bones. Bones cannot maintain their strength without the proper amount of calcium. That is how a lack of calcium results in osteoporosis. It happens when calcium is not deposited well in the bones. This results in porous bones. Porous bones are easy to fracture. Osteoporosis is the fancy name for porous bones.
We know that osteoporosis is because of poor calcium in bones. This means that there is a calcium deficiency. But recent research suggests something else. It shows that heredity might also have a link in causing the disease. We can say that osteoporosis in young people might be a cause of heredity. So, this case might not get solved with calcium intake.
There is a mutation in a certain gene that causes this disease. The gene discovered can open ways for the treatment of the disease. Genetic modification can do wonders.
There is a specific gene SGM2 responsible for proper bone metabolism
The SG2M gene is responsible for a bone enzyme. This bone enzyme regulates bone function. If the enzyme is not present, bone cannot form properly. This can occur due to a genetically mutated gene. This mutation was first discovered in University Hospital Helsinki. The deficiency of this enzyme can cause serious complications.
There is a change in the microstructure of bone. The study can help us understand osteoporosis mechanism. This mechanism can aid us in developing drugs for osteoporosis. This will help us eradicating one of the most challenging mineral diseases.
Children who have this kind of osteoporosis fall prey to fractures. They all have a mutation in their S2GM gene. This leads to a weakened bone structure. Children get fractures, especially in limbs and spine. These fractures occur as a result of minor injuries. This kind of osteoporosis is also linked to neurological symptoms. These symptoms include paralysis of the face.
It occurs because of the enzyme deficiency. The enzyme is not present because of a mutation in the gene. So the facial nerve gets paralyzed. It is one of the common symptoms of osteoporosis.
Mäkitie’s research group Metabolic bone diseases from the University of Helsinki is studying the gene defects. These gene defects include those that increase the risk of osteoporosis. The New Children’s Hospital of the Helsinki University Hospital (HUS) and the Folkhälsan Research Centre is investigating the causes of childhood-onset osteoporosis.